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History

Research started in 1964, commercial production since 1987

In 1964 a Philips 28 MeV AVF cyclotron became operational at the VU University in Amsterdam, the Netherlands, the start of nuclear physics research. Without knowing at the time this small group of committed people laid the foundation of BV Cyclotron VU. 

In 1986 the Dutch government decided that with the new large accelerators at CERN, there was no place for a particle accelerator in the Netherlands anymore. Not wanting to dismantle the cyclotron, a small group of engineers founded in 1987 BV Cyclotron VU and the company rapidly developed into a well-established producer of radiopharmaceuticals and radionuclides used in imaging techniques such as PET and SPECT.  

From the Mathematics and Nature building of VU University we operated with three cyclotrons and various GMP production units to produce our radiopharmaceuticals and GMP radionuclides.

Recently, we have moved to the Amsterdam UMC Imaging Center. The Imaging Center is unique in combining sustainable state-of-the-art imaging techniques, tracer development facilities and experts from various disciplines, focused on patient care and research and development.

With the support of BV Cyclotron VU, the Amsterdam UMC Imaging Center will contribute to the development of new tracers and the testing of new therapies for leading international leaders in the biotech and pharmaceutical industry.

Our three new IBA Cyclone Kiubes offer the highest production capacity ever reached with a 18 MeV cyclotron. In addition, we have the latest GMP hotlabs, making us one of the best-equipped centers for the production of radiopharmaceuticals in the Benelux and one of the first commercial manufacturers of GMP-compliant Zirconium-89 in the world.

Our team now consists of about 50 passionate people who are happy to contribute to better care.

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  • 1964

    Installation of a 28 MeV Philips cyclotron for research

  • 1985

    Start of production of 81Rb/81mKr generators

  • 1987

    Cyclotron-group becomes an independent organization

  • 1992

    First Zirconium-89 (89Zr) production

  • 1997

    Installation of first IBA 18/9 cyclotron; Start of commercial supply of (18F) FDG

  • 2004

    Installation of second IBA 18/9 cyclotron

  • 2008

    Start of commercial supply of Zirconium-89 in cooperation with IBA

  • 2009

    Installation of third IBA 18/9 cyclotron

  • 2012

    Start of decommissioning of Philips cyclotron

  • 2014

    Start of commercial supply of (18F) NeuraCeq®

  • 2017

    Start of commercial supply of (18F) FCholine

  • 2019

    Opening new Imaging Center

  • 2021

    First production F-18 on the new Kiubes

  • 2022

    GMP Licensed for new production site

  • 2023

    First commercial productions from the new site

  • 2024

    Check Check

    Transition from old facility to Imaging Center completed

  • 2025

    Check Check

    Registration PYLCLARI® (piflufolastat (18F))

BV Cyclotron VU

A global health science company that produces radiopharmaceuticals and radiochemicals for medical diagnostics and research

Address

Van der Boechorststraat 6A
1081 BT  Amsterdam
The Netherlands

Contact

+31-20 444 91 23

info@cyclotron.nl

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