Florbetaben: 18F-labeled radiotracer used in PET

Florbetaben (Neuraceq) is an 18F-labeled radiotracer used in PET.
It is currently undergoing global clinical development [1] for use in in vivo mapping of extracellular fibrillar amyloid ß (Aß), a pathological characteristic of Alzheimers disease.

Even though techniques such as FDG-PET and MRI have been successfully applied in the diagnosis of dementia, they are not specific for Alzheimers disease. In recent years, this has led to a quest for more suitable positron-emitting radiotracers, based on the chemistry of dyes used in histological staining. Promising new radiopharmaceuticals, such as the Pittsburgh Compound B (11C-PiB), have been the result. Nevertheless, [11C] cannot be ideally commercialized , so that radiotracers labeled with the more suitable radionuclide [18F], such as Florbetaben, have been intensively evaluated in phases II and III clinical trials [2].

Please note that Florbetaben is currently only available for clinical trials.

Where to buy
Order 18F-Florbetaben from our distribution partner IBA arrow.
Info request about IBA products can be directly sent to Radiopharmaceuticals.Netherlands@curiumpharma.com


[1] Barthel H, Gertz HJ, Dresel S, Peters O, Bartenstein P, Buerger K, Hiemeyer F, Wittemer-Rump SM, Seibyl J, Reininger C, Sabri O; for the Florbetaben Study Group (2011). Cerebral amyloid-β PET with florbetaben ((18)F) in patients with Alzheimers disease and healthy controls: a multicentre phase 2 diagnostic study. Lancet Neurol 10 (5): 424-435.

[2] Vallabhajosula S (2011). Positron emission tomography radiopharmaceuticals for imaging brain Beta-amyloid. Semin Nucl Med 41 (4): 283-299.